Glucose-Responsive Disassembly of Polymersomes of Sequence- Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions

Hyunkyu Kim, Young Ji Kang, Eun Sun Jeong, Sebyung Kang, and Kyoung Taek Kim

http://pubs.acs.org/doi/abs/10.1021/mz3004192

This group co-polymerized organicboronic acid functionalized styrene with functionalized maleimide groups through RAFT. This polymer self-assembled into polymersomes in water and was shown to bind sugars in water at neutral pH. At a high concentration of glucose (>0.3M), the polymersomes would dissassemble.