This paper outlines the synthesis and thorough characterization of
core-shell nanoparticles to be used in pH and ultrasound drug delivery.
These particles feature an iron oxide core surrounded by a mesopourous
silica shell that is capable of harboring a payload of drug molecules.
The drugs are held inside by an outer layer of crown ethers that chelate
metal ions such as Cs+. This outer layer also helps reduce cytotoxicity
in addition to protecting the particles in vivo. These nanoparticles
also displayed high r2 relaxivity.
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