http://www.pnas.org/content/109/26/10175.full.pdf+html
Ting Luo, Jianqing Yu, Jenny Nguyen, Chun-Rong Wang, Robert G. Bristow,
David A. Jaffray, Xiao Zhen Zhou, Kun Ping Lu, and Qing-Bin Lu
Combination therapy with cisplatin and N,N,N',
N'-tetramethyl-p-phenylenediamine (TMPD) enhanced the mechanism of
cisplatin through a dissociative electron transfer reaction as observed
by spectroscopic studies and gel electrophoresis. TMPD reduced the dose
of cisplatin required. Even in cisplatin resistance human ovarian cells
(NIH:OVCAR-3), cancer cells did not survive with cisplatin and TMPD
combination treatment.
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