Macromolecular HPMA-Based Nanoparticles with Cholesterol for Solid-Tumor Targeting: Detailed Study of the Inner Structure of a Highly Efficient Drug Delivery System

Biomacromolecules

http://pubs.acs.org/doi/abs/10.1021/bm3008555

The basic structure of the drug conjugates consists of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer bearing the anticancer drug doxorubicin (Dox) bound via a pH-sensitive hydrazone bond and a defined amount of cholesterol moieties that vary in hydrophobicity. The results show that size, anisotropy, and aggregation number N_aggr of the nanoparticles grows with increasing cholesterol content.  Most of the paper was about theoretical calculation/simulation. No drug delivery data available.