http://pubs.acs.org/doi/full/10.1021/nn301949y
Sentinel lymph mapping is used to track the initial metastasis of cancer
cells to the lymph system and is used to determine biopsy sites and
used during surgery. The authors prepared a self-assembling nanogel from
pullulan-cholesterol conjugated to a NIR emitting dye. The nanogels
were prepared to be 30 nm diameter, which falls in the optimal range for
uptake into the lymphatic system but will not move out of the sentinel
lymph node into the second-tier nodes. The nanogels were found to
increase the lifespan of the dye, effectively map to the SLN, and were
able to be used for real-time imaging in both small (mice) and large
(pig) animals.
No comments:
Post a Comment