Synthesis and Cell Adhesive Properties of Linear and Cyclic RGD Functionalized Polynorbornene Thin Films

Biomacromolecules


http://pubs.acs.org/doi/abs/10.1021/bm300795y
Paresma R. Patel, Rosemary Conrad Kiser, Ying Y. Lu, Eileen Fong, Wilson C. Ho, David A. Tirrell and Robert H. Grubbs

This paper reported a efficient synthesis and evaluation of bioactive arginine-glycine-aspartic acid (RGD) functionalized polynorbornene-based materials for cell adhesion and spreading. Polymers with cyclic RGD side chains maintained cell adhesion and exhibited comparable integrin binding at a 100-fold lower concentration than those carrying linear RGD peptides. The precise control of monomer incorporation enabled by ROMP allows for quantification of the impact of RGD structure and concentration on cell adhesion and spreading.