Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor- Targeted Delivery of Nanoparticles

Heebeom Koo, Sangmin Lee, Jin Hee Na, Sun Hwa Kim, Sei Kwang Hahn, Kuiwon Choi,
Ick Chan Kwon, Seo Young Jeong, and Kwangmeyung Kim

http://onlinelibrary.wiley.com/doi/10.1002/anie.201206703/full

N-azidoacetyl-D-mannosamine was injected into tumor cells, then PEGylated liposomes with dibenzyl cyclooctyne groups were intraveneously injected to bind to the unnatural sialic acid molecules incorporated within the surface of tumor cells. They tested their system in cells and showed that the liposomes were taken up intracellularly, and also tested and verified liposome uptake in tumor-bearing mice.

DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

Zeyu Xiao, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, and
Omid C. Farokhzad

http://onlinelibrary.wiley.com/doi/10.1002/anie.201204018/abstract

Gold nanoparticles were conjugated with PEG and DNA. The DNA consisted of CG base pairs for doxorubicin loading with one strand terminated with thiols for binding to gold and the complementary strand was functionalized with a ligand (folic acid) to target specific cells. DOX can intercalate within CG base pairs, upon which its fluorescence is quenched, so drug loading can be monitored through fluorescence. With near-IR radiation the gold heats up and denatures the DNA, which releases DOX. This system was also tested in mouse models.

Digital photography for the analysis of fluorescence responses

himon Schwaebel, Oliver Trapp and Uwe H. F. Bunz
http://pubs.rsc.org/en/content/articlepdf/2013/sc/c2sc21412a

 The color change in pyridine substituted cruciform fluorophores (XF) in the presence of different carboxylci acids was evaluated using digital photography to address whether extraction of color from digital photography was a suitable, reproducible equivalent to spectrometers in obtaining quantitative information. Errors in reproducibility in pictures of fluorescent samples can arise from the excitation lamp used, sample positioning, exposure time, and white balance. The authors suggested taking the RGD values from a photograph and converting them into CIE LUV standardized color space, which does not contain brightness information.  One strong recommendation was to use a fixed white blance and slightly underexpose the fluorescent sample. 

Engineering of Complex Order and the Macroscopic Deformation of Liquid Crystal Polymer Networks

Angewandte Chemie International Edition

1. Laurens T. de Haan,
2. Dr. Carlos Sánchez-Somolinos,
3. Dr. Cees M. W. Bastiaansen,
4. Dr. Albertus P. H. J. Schenning^*,
5. Prof. Dr. Dirk J. Broer^*

http://onlinelibrary.wiley.com/doi/10.1002/anie.201205964/abstract

Complex-structured freestanding polymer films with molecular order in three dimensions were prepared through photoalignment of polymerizable liquid crystals. The resulting films deform into cone and saddle shapes upon heating.

Chemoselective Cross-Coupling Reactions with Differentiation between Two Nucleophilic Sites on a Single Aromatic Substrate

Julian Linshoeft, Annika C. J. Heinrich, Stephan A. W. Segler, Paul J. Gates,† and Anne Staubitz* 
http://pubs.acs.org/doi/abs/10.1021/ol302571t

 

The stannyl-boronate above can be made easily from the corresponding bis-stannane by transmetallation with MeLi and quenching with a boronate reagent.  The reactions could be one-pot but have to be sequential.

Functional Graphenic Materials Via a Johnson−Claisen Rearrangement

Sydlik, S. A. and Swager, T. M. (2012), Functional Graphenic Materials Via a Johnson−Claisen Rearrangement. Adv. Funct. Mater.

In spirit of one of Jeremiah's "favorites": 

Graphene oxide (GO) is modified using the Johnson-Claisen rearrangement, an improvement over the group's previously reported GO functionalization methods. By utilizing triethyl orthoacetate (TEOA) as reagent and solvent, the rearrangement installs carbon bonded reactive ester functionalities that are not affected by further reduction of the GO to its more conductive counterpart, Graphene. The ester-functionalized GO was then reduced using sodium borohydride. After reduction, treatment with oxalyl chloride and subsequent reaction with various amines creates amide functionalized graphenes with various properties. By installing propargyl groups, they make a "clickable" graphene surface. Furthermore, by using a sulfonated azide tag, they are able to assess the degree of functionalization by XPS. In an alternate demonstration of the use of their method, they synthesize cationic and anionic graphene derivatives and assemble them in a layer by layer fashion to create graphene sheets up to 12 layers thick.

High Aspect Ratio Sub-15 nm Silicon Trenches From Block Copolymer Templates

Adv. Mater.

Xiaodan Gu , Zuwei Liu , Ilja Gunkel , S. T. Chourou , Sung Woo Hong ,
Deirdre L. Olynick , * and Thomas P. Russell *

http://onlinelibrary.wiley.com/doi/10.1002/adma.201202361/pdf 

High-aspect-ratio sub-15-nm silicon trenches are fabricated directly from plasma etching of a block copolymer mask. A novel method that combines a block copolymer reconstruction process and reactive ion etching is used to make the polymer mask. Silicon trenches are characterized by various methods and used as a master for subsequent imprinting of different materials. Silicon nanoholes are generated from a block copolymer with cylindrical microdomains oriented normal to the surface.