Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments

Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments

M. J. Previs¹, S. Beck Previs¹, J. Gulick², J. Robbins², D. M. Warshaw¹,*

http://www.sciencemag.org/content/337/6099/1215.full

In this paper, the authors pinpoint the role of cardiac myosin-binding protein C in heart disease -- turns out that under-phosphorylation of this protein results in chronic contraction-braking of the heart (cleverly dubbed "heart brakes" in a perspective).