Hydrophobic Interaction-Mediated Capture and Release of Cancer Cells on Thermoresponsive Nanostructured Surfaces

Advanced Materials

Hongliang Liu¹,Xueli Liu^1,2,Jingxin Meng¹,Pengchao Zhang^1,2,Gao Yang²,Bin Su¹,Kang Sun¹,Li Chen¹,Dong Han³,Shutao Wang^1,*,Lei Jiang

http://onlinelibrary.wiley.com/doi/10.1002/adma.201203826/abstract


Capture and release of cancer cells: A thermoresponsive nanostructured surface has been designed to reversibly capture and release cancer cells, wherein hydrophobic interaction helps the realization of target capture/release of cancer cells. The unique nature of our designed platform is based on the synergistic effect of hydrophobic interactions between the smart surface and the hydrophobic anchor (i.e., biotin-BSA), and topographic interactions between the nanostructured substrates and cancer cells. 


Posted by Huaxing Zhou at 11/29/2012 10:54:00 AM