This somewhat clunky paper outlines the synthesis of a multifunctional
pegylated small molecule for use in vivo imaging. The multifunctional
fluorochromes feature a long peg chain, DOTA ligands and an integrin
binding peptide. They discuss the values of pegylation- an increased
quantum yield, decreased interactions and nonspecific binding. Their
mouse imaging studies show a localized signal versus an un-pegylated
control. These are interesting because they look similar to
macromonomers in our arsenal.
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