Wednesday, December 5, 2012

Photoselective Delivery of Model Therapeutics from Hydrogels

http://pubs.acs.org/doi/pdf/10.1021/mz300366s
Donald R. Griffin and Andrea M. Kasko

 Fluorescein, rhodamine, and aminomethylcoumarin acetate were linked to PEG macromers via several different photodegrable ortho-nitrobenzyl based linkers. The macromers were polymerized into gels through redox polymerization using APS (ammonia persulfate) and TEMED (N,N,N',N'-tetramethylenediamine). The rates of degradation and release of the linked molecules were observed at different wavelengths and found to differ for each molecule.

Abstract Image

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