A long winded review of various catalyzed "Domino" or multi-component
reactions. (Really long winded: their list of abbreviations is a page
long.) It's worth a look-though for the diverse sampling of interesting
cross coupling reactions. A representative example involves an
asymmetric aldol condensation-cyclization to yield enriched oxazolines.
Cobalt, coordinated to a chiral ligand, gets extra assistance from a
chiral thiourea to facilitate ordered coordination and cyclization of a
racemic nitrile substrate.
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