Sunday, March 24, 2013

Chitosan-Oxanorbornadiene: A Convenient Chitosan Derivative for Click Chemistry without Metal Catalyst Problem

Jatesuda Jirawutthiwongchai,† Andreas Krause,‡ Gerald Draeger,*,‡ and Suwabun Chirachanchai*,†,§
†The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand
‡Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Hannover 30167,

The authors describe a way of functionalizing chitosan via oxanorbornadiene-azide metal free click.  They monitor the click reaction by FT-IR, proton and fluorine NMR.  The conversions look pretty low and it takes at least 3 days to complete.


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