Sunday, March 24, 2013

Drug delivery, surface effects

The Role of Surface Functionality in Determining Nanoparticle Cytotoxicity
Sung Tae Kim , Krishnendu Saha , Chaekyu Kim , and Vincent M. Rotello *

This review describes "how NP surface properties control interactions with biomolecules and cells at many scales, including the role the particle surface plays in determining in vivo behavior of nanomaterials. These interactions can be benign, beneficial, or lead to dysfunction in proteins, genes and cells, resulting in cytotoxic and genotoxic responses. Understanding these interactions and their consequences helps us to design minimally invasive imaging and delivery agents."

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