Siu-Fung Lee, Xiao-Ming Zhu, Yi-Xiang J. Wang, Shou-Hu Xuan, Qihua You, Wing-Hong Chan, Chi-Hin Wong, Feng Wang, Jimmy C. Yu, Christopher H. K. Cheng, and Ken Cham-Fai Leung ACS Applied Materials & Interfaces Article ASAP
This paper outlines the synthesis and thorough characterization of core-shell nanoparticles to be used in pH and ultrasound drug delivery. These particles feature an iron oxide core surrounded by a mesopourous silica shell that is capable of harboring a payload of drug molecules. The drugs are held inside by an outer layer of crown ethers that chelate metal ions such as Cs+. This outer layer also helps reduce cytotoxicity in addition to protecting the particles in vivo. These nanoparticles also displayed high r2 relaxivity.