Sunday, March 24, 2013

Ultrasound, pH, and Magnetically Responsive Crown-Ether-Coated Core/Shell Nanoparticles as Drug Encapsulation and Release Systems

Abstract Image
This paper outlines the synthesis and thorough characterization of core-shell nanoparticles to be used in pH and ultrasound drug delivery. These particles feature an iron oxide core surrounded by a mesopourous silica shell that is capable of harboring a payload of drug molecules. The drugs are held inside by an outer layer of crown ethers that chelate metal ions such as Cs+. This outer layer also helps reduce cytotoxicity in addition to protecting the particles in vivo. These nanoparticles also displayed high r2 relaxivity.  

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