Sunday, March 24, 2013

Stepwise Click Functionalization of DNA through a Bifunctional Azide with a Chelating and a Nonchelating Azido Group

This paper utilizes cool click chemistry to make heterodimers of nucleosides and oligonucleotides. The bis-azide linker used features a copper coordinating azide site and a regular azide site. The coordinating site will react selectively with an alkyne in the presence of Cu(II)acetate and in the absence of an external reducing agent like sodium ascorbate. The other azide site can then be "clicked" to a different alkyne in the presence of Cu(II)acetate and sodium ascorbate. 

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