This paper utilizes cool click chemistry to make heterodimers of
nucleosides and oligonucleotides. The bis-azide linker used features a
copper coordinating azide site and a regular azide site. The
coordinating site will react selectively with an alkyne in the presence
of Cu(II)acetate and in the absence of an external reducing agent like
sodium ascorbate. The other azide site can then be "clicked" to a
different alkyne in the presence of Cu(II)acetate and sodium ascorbate.
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