Organometallic anticancer agents that interfere with
cellular energy processes: a subtle approach to
inducing cancer cell death†
Alexey A. Nazarov,*a,b Daniel Gardini,a Mathurin Baquié,a
Lucienne Juillerat-Jeanneret,c Tatiana P. Serkova,d Elena P. Shevtsova,d Rosario Scopellitia and Paul J. Dyson*a
"Two hybrid compounds comprising an antimetastatic ruthenium– arene fragment tethered to an indazole-3-carboxylic acid deriva- tive that inhibits aerobic glycolysis in cancer cells have been pre- pared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent syner- gistic action between the two components observed."
Alexey A. Nazarov,*a,b Daniel Gardini,a Mathurin Baquié,a
Lucienne Juillerat-Jeanneret,c Tatiana P. Serkova,d Elena P. Shevtsova,d Rosario Scopellitia and Paul J. Dyson*a
"Two hybrid compounds comprising an antimetastatic ruthenium– arene fragment tethered to an indazole-3-carboxylic acid deriva- tive that inhibits aerobic glycolysis in cancer cells have been pre- pared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent syner- gistic action between the two components observed."
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