Sunday, June 24, 2012

Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and α-Carbonyl Aldehyde: A Practical and Efficient Approach to α-Ketoamides with Wide Substrate Scope

Org. Lett.

A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with alpha -carbonyl aldehyde has been developed. Mechanism studies show that carbonyl group of alpha-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process

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