Sunday, June 10, 2012

CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines

Org. Lett. 

DMPAO has been found to be a powerful ligand to enable copper-catalyzed coupling of aryl halides with aliphatic acyclic secondary amines take place under relatively mild conditions, and coupling of aryl halides with primary amines and cyclic secondary amines proceeds at low catalyst loading. 

Abstract Image 

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