Rong Tong, Houman D. Hemmati, Robert Langer, and Daniel S. Kohane
Journal of the American Chemical Society 2012 134 (21), 8848-8855
This drug delivery system utilizes a "photo-switchable" nano-particle
composed of an outer layer of hybrid spyropyran-lipid-PEG chains and in
inner core of photo-releasable drug molecules . When irradiated under UV
light, spyropryan reversibly isomerizes in a way that causes the volume
of the nanoparticle to contract. This contraction is hypothesized to
enhance tumor penetration to make for a more effectively delivered drug
that can be "repetitively dosed from a single administration."
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