Reservoir-based drug delivery systems utilizing microtechnology

Reservoir-based drug delivery systems utilizing microtechnology
Cynthia L. Stevenson a, John T. Santini Jr. a,⁎, Robert Langer

http://www.sciencedirect.com/science/article/pii/S0169409X12000282


This paper discusses various types of drug delivery systems: from microneedle-based ones, to microchannel implants, membrane-based ones, as well as active delivery systems (stimulus-based). 

Self-folding polymeric containers for encapsulation and delivery of drugs

Rohan Fernandesa, David H. Graciasa,

http://www.sciencedirect.com/science/article/pii/S0169409X12000919

This review discusses a topic related to one we recently heard a talk about (the one about encoding 3D-shape into materials using selective photocrosslinking).  In this case, materials are encoded to fold up into containers of specific shape, with selectively-derivatized faces.  The interior could be used to transport drugs.

Ultrafast Photoinduced Processes in Subphthalocyanine Electron Donor Acceptor Conjugates Linked by a Single B N Bond

Carlos Romero-Nieto,† Julia Guilleme,‡ Javier Fern andez-Ariza,‡ M. Salom e Rodr ́ıguez-Morgade,‡ David Gonz alez-Rodr ́ıguez,‡ Tom as Torres,*,‡,§ and Dirk M. Guldi*,† 

http://pubs.acs.org/doi/abs/10.1021/ol302632u 

This paper is interesting because it presents interesting boron-containing lewis acids, in which the boron is embedded into a photo-active structure. 

Nitroso-Dienophile Additions to Dendralenes: A Short Synthesis of Branched Aminosugars

Ruomeng Wang,† Gomotsang Bojase,† Anthony C. Willis,†,§ Michael N. Paddon-Row,*,‡ and Michael S. Sherburn*,†

http://pubs.acs.org/doi/abs/10.1021/ol302619r

This paper serves as a good example of [n]dendralene reactivity.  These might be useful as Diels-Alder crosslinking agents, although the reactivity of the "dienes" embedded within the dendralene is not necessarily equivalent (so equivalent reactivity of termini might not hold).

Autonomous motors of a metal-organic framework powered by reorganization of self-assembled peptides at interfaces

http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat3461.html

The authors made a copper-containing MOF loaded with diphenylalanine (DPA) peptides. When the MOFs are placed in an EDTA solution, EDTA chelates copper out of the MOF, releasing DPA in a controlled unidirectional manner. The DPA self-assembles at the MOF/water interface into a region of lower surface tension. The MOFs then move away from the self-assembled DPA toward the region of higher surface tension, as per the Marangoni Effect. MOF lifetime and velocity increase with increasing DPA loading.

Glucose-Responsive Disassembly of Polymersomes of Sequence- Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions

Hyunkyu Kim, Young Ji Kang, Eun Sun Jeong, Sebyung Kang, and Kyoung Taek Kim

http://pubs.acs.org/doi/abs/10.1021/mz3004192

This group co-polymerized organicboronic acid functionalized styrene with functionalized maleimide groups through RAFT. This polymer self-assembled into polymersomes in water and was shown to bind sugars in water at neutral pH. At a high concentration of glucose (>0.3M), the polymersomes would dissassemble.

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

Control and Design of Mutual Orthogonality in Bioorthogonal Cycloadditions
Yong Liang, Joel L. Mackey, Steven A. Lopez, Fang Liu, and K. N. Houk

http://pubs.acs.org/doi/pdf/10.1021/ja309241e

The azide–dibenzocyclooctyne and trans-cyclooctene–tetrazine cycloadditions are both bioorthogonal and mutually orthogonal: trans-cyclooctene derivatives greatly prefer to react with tetrazines rather than azides, while dibenzocyclooctyne derivatives react with azides but not with tetrazines under physiological conditions. DFT calculations used to identify the origins of this extraordinary selectivity are reported, and design principles to guide discovery of new orthogonal cycloadditions are proposed. Two new bioorthogonal reagents, methylcyclopropene and 3,3,6,6-tetramethylthiacycloheptyne, are predicted to be mutually orthogonal in azide and tetrazine cycloadditions.