Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition

Advanced Materials

http://onlinelibrary.wiley.com/doi/10.1002/adma.201202225/abstract

A novel class of antimicrobial cationic polycarbonate/PEG hydrogels were designed and synthesized by Michael addition. These hydrogels demonstrate strong broad-spectrum anti-microbial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.