http://onlinelibrary.wiley.com/doi/10.1002/adma.201202932/pdf
A new method for tuning plasmid DNA nanoparticles by varying solvent polarity during the condensation of DNA with PEG- b -polyphosphoramidate (PPA). Upon separately dissolving the copolymer and plasmid DNA in dimethylformamide (DMF)–water mixtures at fixed volumetric ratios and mixing the two solutions at a predetermined copolymer-to-DNA ratio to achieve effective DNA condensation, a striking variation was observed in morphology.
No comments:
Post a Comment