Electrografting of calix[4]arenediazonium salts to form versatile robust platforms for spatially controlled surface functionalization

Alice Mattiuzzi, Ivan Jabin, Claire mangeney, Clément Roux, Olivia Reinaud, Luis Santos, Jean-François Bergamini, Philippe Hapiot & Corinne Lagrost

http://www.nature.com/ncomms/journal/v3/n10/full/ncomms2121.html

"Calix[4]tetra-diazonium cations generated in situ from the corresponding tetra-anilines were electrografted on gold and carbon substrates. The well-preorganized macrocyclic structure of the calix[4]arene molecules allows the formation of densely packed monolayers. Through adequate decoration of the small rim of the calixarenes, functional molecules can then be introduced on the immobilized calixarene subunits, paving the way for an accurate spatial control of the chemical composition of a surface at molecular level."  One cool experiment is determination of surface coverage by functionalizing the electrode with COOH terminated calixarenes and then coupling on Fc moieties and doing CV.