One-Pot Cascade Synthetic Strategy: A Smart Combination of Chemoenzymatic Transesterification and Raft Polymerization

Shiqi Wang, Changkui Fu, Yun Zhang, Lei Tao, Shuxi Li, and Yen Wei

http://pubs.acs.org/doi/pdf/10.1021/mz300444w

In one pot, enzymatic transesterification (by Novozym435) was performed between a primary alcohol and an acyl donor ligand (2,2,2-trifluoroethyl methacrylate) followed by RAFT polymerization of the resulting product. Kinetic studies, GPCs, and NMRs were obtained to characterize and monitor the reaction.