Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

Jonathan K. Lam,† Yvonne Schmidt,† and Christopher D. Vanderwal*

http://pubs.acs.org/doi/abs/10.1021/ol302680m

 

In this paper, the authors report an interesting two-step route for conversion of various analogs of amide above to the corresponding tricyclic structures.  The two steps are (1) alkyne-allene isomerization/intramolecular Diels Alder cycloaddition and (2) ROM-RCM.