Andrzej Rajca, Ying Wang, Michael Boska, Joseph T. Paletta, Arnon
Olankitwanit, Michael A. Swanson, Deborah G. Mitchell, Sandra S. Eaton,
Gareth R. Eaton, and Suchada Rajca Journal of the American Chemical Society 2012 134 (38), 15724-15727
This paper presents an all-organic MRI contrast agent that utilizes the
paramagnetic nature of persistant nitroxide radicals. Spriocyclohexyl
nitroxide radical structures are built into a dendrimer scaffold that is
pegylated at the last level. The study includes assays on the EPR
activity of the dendrimers, the reduction rate of the nitroxide radicals
in mock-vivo conditions, and in-vivo imaging.
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