Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration
Philipp S. Lienemann a,b, Matthias P. Lutolf b, Martin Ehrbar a,c,⁎
This quote from the review summarizes it very well:
"In an ideal situation, the localized delivery of growth factors
should present physiologically relevant doses and preserve its activity
for prolonged periods of time. Moreover, carrier materials should
facilitate the communication with cells of the host so as to be actively
involved in the process of regeneration. Synthetic hydrogels, highly
swollen three-dimensional (3D) networks of macromolecules, have emerged
as powerful candidate biomaterials to fulfil these requirement."
As indicated in the image below, the focus is on hydrogels that can
serve as extracellular matrix mimics. Embedded in the hydrogel, either
covalently or not, are growth factors.