Angewandte Chemie International Edition
This article, published in 2004, describes the first prodrug system with
the ability to release three different anticancer drugs in the presence
of antibody 38C2. The authors covalently bind Campthocein,
Doxorubicin, and Etoposide to a single enzyme substrate and show the
release of all drugs after addition of antibody 38C2. Antibody 38C2
cleaves the enzyme substrate and triggers retro-aldol and retro-Michael
reactions that in turn cleaves the drugs.