Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments
M. J. Previs1, S. Beck Previs1, J. Gulick2, J. Robbins2, D. M. Warshaw1,*
In this paper, the authors pinpoint the role of cardiac myosin-binding
protein C in heart disease -- turns out that under-phosphorylation of
this protein results in chronic contraction-braking of the heart
(cleverly dubbed "heart brakes" in a perspective).