Wednesday, December 5, 2012

Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor- Targeted Delivery of Nanoparticles

Heebeom Koo, Sangmin Lee, Jin Hee Na, Sun Hwa Kim, Sei Kwang Hahn, Kuiwon Choi,
Ick Chan Kwon, Seo Young Jeong, and Kwangmeyung Kim

N-azidoacetyl-D-mannosamine was injected into tumor cells, then PEGylated liposomes with dibenzyl cyclooctyne groups were intraveneously injected to bind to the unnatural sialic acid molecules incorporated within the surface of tumor cells. They tested their system in cells and showed that the liposomes were taken up intracellularly, and also tested and verified liposome uptake in tumor-bearing mice.

Thumbnail image of graphical abstract

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