Heebeom Koo, Sangmin Lee, Jin Hee Na, Sun Hwa Kim, Sei Kwang Hahn, Kuiwon Choi,
Ick Chan Kwon, Seo Young Jeong, and Kwangmeyung Kim
N-azidoacetyl-D-mannosamine was injected into tumor cells, then
PEGylated liposomes with dibenzyl cyclooctyne groups were intraveneously
injected to bind to the unnatural sialic acid molecules incorporated
within the surface of tumor cells. They tested their system in cells and
showed that the liposomes were taken up intracellularly, and also
tested and verified liposome uptake in tumor-bearing mice.