Yanyan Guo, Hushan Yuan, William L. Rice, Anand T. N. Kumar, Craig J. Goergen, Kimmo Jokivarsi, and Lee Josephson Journal of the American Chemical Society Article ASAP
This somewhat clunky paper outlines the synthesis of a multifunctional pegylated small molecule for use in vivo imaging. The multifunctional fluorochromes feature a long peg chain, DOTA ligands and an integrin binding peptide. They discuss the values of pegylation- an increased quantum yield, decreased interactions and nonspecific binding. Their mouse imaging studies show a localized signal versus an un-pegylated control. These are interesting because they look similar to macromonomers in our arsenal.