Wednesday, December 5, 2012

The PEG-Fluorochrome Shielding Approach for Targeted Probe Design

Abstract Image
This somewhat clunky paper outlines the synthesis of a multifunctional pegylated small molecule for use in vivo imaging. The multifunctional fluorochromes feature a long peg chain, DOTA ligands and an integrin binding peptide. They discuss the values of pegylation- an increased quantum yield, decreased interactions and nonspecific binding. Their mouse imaging studies show a localized signal versus an un-pegylated control. These are interesting because they look similar to macromonomers in our arsenal.

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