Wednesday, December 5, 2012

Recent Developments in Enantioselective Metal-Catalyzed Domino Reactions

A long winded review of various catalyzed "Domino" or multi-component reactions. (Really long winded: their list of abbreviations is a page long.) It's worth a look-though for the diverse sampling of interesting cross coupling reactions. A representative example involves an asymmetric aldol condensation-cyclization to yield enriched oxazolines. Cobalt, coordinated to a chiral ligand, gets extra assistance from a chiral thiourea to facilitate ordered coordination and cyclization of a racemic nitrile substrate. 

No comments:

Post a Comment