Wednesday, December 5, 2012

DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

Zeyu Xiao, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, and
Omid C. Farokhzad

Gold nanoparticles were conjugated with PEG and DNA. The DNA consisted of CG base pairs for doxorubicin loading with one strand terminated with thiols for binding to gold and the complementary strand was functionalized with a ligand (folic acid) to target specific cells. DOX can intercalate within CG base pairs, upon which its fluorescence is quenched, so drug loading can be monitored through fluorescence. With near-IR radiation the gold heats up and denatures the DNA, which releases DOX. This system was also tested in mouse models.

Thumbnail image of graphical abstract

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