Wednesday, December 5, 2012

Multifunctional Non-Viral Delivery Systems Based on Conjugated Polymers

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This review covers recent developments of a few potential biomedical applications conjugated polymers (CPs). CPs have a variety of properties that lend themselves to non-viral delivery systems of SiRNA, DNA plasmids and proteins. Cationic conjugated polymers are generally used to form nanoparticles with negatively charged biomolecules through electrostatic interactions. These nanoparticles have enhanced cell permeability and are easily monitored by fluorescence microscopy. 

 Some examples of CPs that are discussed in this review: poly(fluorene-co-phenylene) (PFP), poly(p-phenylenevinylene) (PPV), poly(p-phenyleneethynylene) (PPE), polydiacetylene (PDA), and polythiophene (PT)

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