Zhengbao Zha,Xiuli Yue,Qiushi Ren,Zhifei Dai
Uniform polypyrrole (PPy) nanoparticles were fabricated from a facile one-step aqueous dispersion polymerization.
Owing to their high photothermal conversion efficiency and
photostability compared with the well-known Au nanorods, as well as
their good colloidal stability and biocompatibility, the resulting PPy
nanoparticles could be used as a novel promising photothermal ablation
coupling agent for targeted treatment of cancer.
Au nanorods have low photostability since their NIR absorbance peak
would diminish after a long period of laser irradiation due to the
“melting effect”; whereas other inorganic nanomaterials, such as carbon
nanomaterials,and copper sulfide nanoparticles, which have also been
shown to generate sufficient photothermal heating by NIR light
illumination to destroy cancer cells, are non-biodegradable and usually
remain in the body for long periods of time.