Wednesday, December 5, 2012

Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells

Advanced Materials

Zhengbao Zha,Xiuli Yue,Qiushi Ren,Zhifei Dai

Uniform polypyrrole (PPy) nanoparticles were fabricated from a facile one-step aqueous dispersion polymerization. Owing to their high photothermal conversion efficiency and photostability compared with the well-known Au nanorods, as well as their good colloidal stability and biocompatibility, the resulting PPy nanoparticles could be used as a novel promising photothermal ablation coupling agent for targeted treatment of cancer.

Au nanorods have low photostability since their NIR absorbance peak would diminish after a long period of laser irradiation due to the “melting effect”; whereas other inorganic nanomaterials, such as carbon nanomaterials,and copper sulfide nanoparticles, which have also been shown to generate sufficient photothermal heating by NIR light illumination to destroy cancer cells, are non-biodegradable and usually  remain in the body for long periods of time.

Thumbnail image of graphical abstract

No comments:

Post a Comment