Thursday, February 7, 2013

NMP of drug loaded isoprene nanoparticles

Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug
Amphiphiles Prepared by Living Radical Polymerization
Simon Harrisson, Julien Nicolas, Andrei Maksimenko, Duc Trung Bui, Julie Mougin, and
Patrick Couvreur

This paper details the synthesis and use of gemcitabine loaded polyisoprene nanoparticles of 130-160 nm as a way of delivering anticancer drugs without the 'burst effect.' They discuss attachment of a non-polar polymer backbone to a polar drug like gemicitabine as a type of pro-drug delivery, allowing the highly cytotoxic gemitabine to be released more slowly. They found that higher molecular weight polymers (and therefore more hydrophobic nanoparticles) showed the greatest anticancer activity.

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