Thursday, February 7, 2013

Positively Charged Dendron Micelles Display Negligible Cellular Interactions

Ryan M. Pearson,Niladri Patra,§ Hao-jui Hsu,Sayam Uddin,Petr Kraĺ,§,and Seungpyo Hong*,,

ACS Macro Lett. 2013, 2, 77−81

Study of surface-modified PEGylated dendron-based copolymers with -NH2, -COOH, -Ac and -OMe end-group functionalities.  It was demonstrated that the micelles did not exhibit charge-dependent cellular interactions as expected which could be a result of high molecular weight to surface ratio and/or the orientation of the end groups (H-bonding).  In addition, the dendron micelles were found to be nontoxic up to concentrations of 100 uM making them potential drug delivery systems.

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