The authors designed a synthetic lectin for glucose binding and sensing.
The synthetic lectin is synthesized in five steps with 23% overall
yield. It exhibits a moderate binding affinity for glucose and a change
in fluorescence upon glucose complexation with slow photobleaching which
makes it good for glucose sensing applications. The host-guest complex
was characterized by NMR with distinct peak shifts observed on binding.
The synthetic lectin shows high chemoselectivity, binding glucose
preferentially to galactose (50:1) and showing no binding of lactate or
mannitol (other carbohydrates found in the blood). These aspects make
this molecule feasible for applications in blood glucose sensing.