Monday, August 20, 2012

A simple and accessible synthetic lectin for glucose recognition and sensing

The authors designed a synthetic lectin for glucose binding and sensing. The synthetic lectin is synthesized in five steps with 23% overall yield. It exhibits a moderate binding affinity for glucose and a change in fluorescence upon glucose complexation with slow photobleaching which makes it good for glucose sensing applications. The host-guest complex was characterized by NMR with distinct peak shifts observed on binding. The synthetic lectin shows high chemoselectivity, binding glucose preferentially to galactose (50:1) and showing no binding of lactate or mannitol (other carbohydrates found in the blood). These aspects make this molecule feasible for applications in blood glucose sensing.

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