This paper reported a efficient synthesis and evaluation of bioactive
arginine-glycine-aspartic acid (RGD) functionalized polynorbornene-based
materials for cell adhesion and spreading Polymers with cyclic RGD side chains maintained cell adhesion and
exhibited comparable integrin binding at a 100-fold lower concentration
than those carrying linear RGD peptides. The precise control of monomer
incorporation enabled by ROMP allows for quantification of the impact of
RGD structure and concentration on cell adhesion and spreading.