Monday, August 20, 2012

Boronic Acid Terminated Thermo-Responsive and Fluorogenic Polymer

The authors create a boronic acid-terminated pNIPAAm via ATRP and CuAAC click chemistry. Boronic acids are known to bind cis-diol saccharides and exhibit a change in fluorescence. Using boronic acid terminated NIPAAm, the authors demonstrate the ability to sense fructose by changes in fluorescence spectrometry and the ability to remove fructose by thermo-aggregation of NIPAAm. The synthesis of the polymer is simple, involving no protection/deprotection, and results in a terminal bromine that can be used for further functionalization and conjugation.

No comments:

Post a Comment