A set of monofunctionalized platinum complexes were synthesized with the
general formula: cis-[Pt(NH3)2(N-heterocycle)Cl]Cl. In particular,
complexation to phenanthridin showed enhanced cytotoxic behaviour
compared to other tested N-heterocycles, cisplatin, or oxaliplatin.
Cellular uptake was shown to be higher likely as a result of the
N-heterocycle. As well, in studies comparing binding of these complexes
with 5'-deoxyguanosine monophosphate and N-acetyl methionine, the
phenanthridin showed better binding to the nucleotide suggesting it
might overcome drug resistance that results from interactions with
sulfur based compounds.