Monday, August 20, 2012

Thiol-Selective Fluorogenic Probes for Labeling and Release

Vu Hong, Alexander A. Kislukhin, and M. G. Finn Journal of the American Chemical Society 2009 131 (29), 9986-9994

This article outlines a technique that utilizes thiol-ene chemistry to link peptides and other molecules together. When the thiol reacts with the oxonorbornadiene moiety, it activates a fluorescent dye that is attached. These adducts decompose readily via reverse Diels-Alder.

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