Design, Synthesis, and Biological Evaluation of Novel cRGD-Paclitazel Conjugates for Integrin-Assisted Drug Delivery

http://pubs.acs.org/doi/full/10.1021/bc300164t

The authors synthesized and screened nine different RGD-based peptides (varying cyclic vs. linear, spacers, linkers, etc). They examined integrin-binding affinity, cytotoxicity, and comparison to free Paclitaxel in vivo. Their findings might be interesting for our work on targeted drug delivery.