Monday, August 20, 2012

PolyMPC-Doxorubicin Prodrugs

The authors prepared poly(methacryloyloxyethyl phosphorylcholine) (polyMPC) linked to Dox via a hydrazone linkage using a one-pot ATRP/click reaction. They then test the pro-drug for solubility and stability at physiological conditions and in vitro uptake. They also examine the acid-assisted cleavage of the hydrazone for Dox release.

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