Saturday, August 4, 2012

Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

The authors made nanogels from zwitterionic poly(carboxybetaine). Using different crosslinking densities they made softer and stiffer (as measured by bulk modulus) nanogels with similar hydrodynamic radii and encapsulated gold nanoparticles. They demonstrate that the softer gels are able to pass through filters smaller than their particle size while stiffer gels could not. They also showed that softer gels have a longer blood circulation time and lower accumulation in the spleen, suggesting that because of their capability to deform softer gels survive the filtration and clearance mechanisms of the reticuloendothelial system.

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