Monday, August 20, 2012

Highly Emissive Conjugated Polyelectrolyte Vector for Gene Delivery and Transfection

Advanced Materials.

An intrinsically fl uorescent cationic polyfl uorene ( CCP ) has been designed, synthesized, characterized, and examined as a plasmid DNA (pDNA) delivery vector.
CCP can effectively protect pDNA against nuclease degradation, which is necessary for gene carriers. Green fluorescent protein (GFP) expression experiments reveal that CCP can achieve efficient delivery and transfection of pDNA encoding GFP gene with 92% efficiency, which is higher than some of the commercial transfection agents.

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