Monday, August 20, 2012

Near-Infrared Emitting Polymer Nanogels for Efficient Sentinel Lymph Node Mapping

Sentinel lymph mapping is used to track the initial metastasis of cancer cells to the lymph system and is used to determine biopsy sites and used during surgery. The authors prepared a self-assembling nanogel from pullulan-cholesterol conjugated to a NIR emitting dye. The nanogels were prepared to be 30 nm diameter, which falls in the optimal range for uptake into the lymphatic system but will not move out of the sentinel lymph node into the second-tier nodes. The nanogels were found to increase the lifespan of the dye, effectively map to the SLN, and were able to be used for real-time imaging in both small (mice) and large (pig) animals.
Abstract Image

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