Microarray with Micro- and Nano-topographies Enables
Identification of the Optimal Topography for Directing the
Differentiation of Primary Murine Neural Progenitor Cells
Aung Aung Kywe Moe,
et al.
http://onlinelibrary.wiley.com/doi/10.1002/smll.201200490/abstract
In this paper, the authors present a study of topography-dependence
of murine neural progenitor cell differentiation. They find that these
cells differentiate into neurons by anisotropic gratings (2 μm
gratings, 250 nm gratings) and isotropic 1 μm pillars, as indicated by
expression of β-III-tubulin (59%, 58%, and 58%, respectively, compared
to 30% on the control). In contrast, glial differentiation is enhanced
on isotropic 2 μm holes and 1 μm pillars.
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