Sunday, July 15, 2012

E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells

Michael J. Mitchell, Christina S. Chen, Varun Ponmudi, Andrew D. Hughes, and Michael R. King

Liposomal doxorubicin with PEG and E-selectin coupled to the surface were used to study the possibility of targetting circulating tumor cells in the bloodstream. The E-selectin (selectins are naturally found on imflamed endothelial cells) was able to adhere to sialylated carbohydrate ligands that are often overexpressed on circulating tumor cells. The researchers were able to show that their nanoparticles immobilized along microtubules or in a cone-and-plate viscometer were able to target and kill cancer cells under shear flow, but not red blood cells.

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